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资源学

2023年11月07日

专业特色

药用植物资源与保护研究中心（简称资源中心）是建所以来最早成立的研究中心之一，主要开展药用植物资源保护与可持续利用方向的研究工作，同时还开设《药用植物资源学》、《药用植物分类与实践》、《药用植物生理学》等面向研究生教育课程，形成了以药用植物学为基础，广泛利用遗传学、生理学、植物化学、药理学、生物信息学、分子生物学等多学科交叉的现代技术方法研究药用植物资源与保护的科研与教学中心。

研究方向

  1. 药用植物资源调查与评估； 2、药用植物分类与鉴定；3、珍稀濒危药用植物保护与开发；4、药用植物地理分布与生态；5、药用植物优良品质及性状形成机制研究； 6、药用植物种质资源收集及品质评价；7、中药材GAP实施与管理；8、药用植物资源化学；9、中药创新药物研发；10、药用植物基因组与合成生物学。

师资力量及人才培养

中心现有职工16名，含博士生导师5名，硕士生导师5名。本中心拥有海外优青获得者、“协和新星”、北京市及协和医学院优秀教师等多项荣誉称号，先后培养硕士、博士毕业生100多人

科研水平

资源中心在药用植物资源调查、中药材品质评价等方向处于国内领先水平，目前在大宗常用药材品种的资源调查、栽培技术标准，濒危药用植物资源调查与评估、大宗药材质量评价与品质形成机制、药用植物基因组学、中药材外源污染真菌和有毒药用植物分子鉴定等基础与应用开发方面正在开展深入而广泛的研究。

重大课题

资源中心先后承担各类国家级、省部级科研项目80余项，其中包括国家自然科学基金、海外优青、国家重点研发计划项目、“重大新药创制”科技重大专项、国家中药标准化项目、科技部科技基础性工作专项、国家中医药管理局中医药行业科研专项、科技部“十二·五”国家科技支撑计划项目等项目。

发表文章及科研成果

主持或参与编写专著10余部，包括《中国药用植物红皮书》、《中国药典中药材DNA 条形码标准序列》、《药用植物科普笔记》、《本草基因组学》、《植物基因工程》（第二版）等，发表科研论文500余篇。获得国家科学技术进步二等奖及省部级等重要奖项10余项；获授权发明专利20余项，软件著作权10余项。参与制定国家、行业及地方标准20余项。

代表性成果：

  1. Zhiwei Li†, Yufan Feng†, Haitao Liu†, Hongqin Yang, Jinqiu Li, Yitian Zhou, Junling Pang, Peiran Yang, Hongmei Zhao*, Jing Wang*. Single-cell transcriptomics of mouse lung reveal inflammatory memory neutrophils in allergic asthma. Allergy. 2022, 77(6): 1911-1915.
  2. Zhangjian Shan#, Qian Zhang#, Yaodong Qi#, Jianfei Ye, Dacheng Hao, Peigen Xiao, Lan Cao, Jiahui Sun, Lina Zhao, Yanting Niu, Danxiao Peng, Limin Lu, Zhiduan Chen. Production regionalization of commonly used medicinal plants in China based on botanical big data. Industrial Crops and Products, 2023, 202: 117024.
  3. Ruyu Yao, Michael Heinrich, Bengang Zhang, Xueping Wei, Yaodong Qi*, Weiwei Gao1*. Single botanical drugs in the Ayurvedic Pharmacopoeia of India—A quantitative ethnobotanical analysis. Frontiers in Pharmacology, 2023, 14: 1136446.
  4. Jiejing Gao, Tiantian Xue, Changying Xia, Chunfeng Tang, Fei Qin, Xudong Yang, Jiaxin Wang, Yunfeng Huang, Yaodong Qi*, Rainer W. Bussmann*, Chong Luo*, Shengxiang Yu*. Priority management measures based on analyses of conservation effectiveness and threat factors for medicinal plants used by three ethnic groups in China. Biological Conservation, 2023, 283: 110120.
  5. Bin Li#, Qi Xiao#, Jianuo Zhang, Yumeng Wang, Jiushi Liu, Bengang Zhang, Haitao Liu*. Exploring the active compounds and potential mechanism of the anti-nonalcoholic fatty liver disease activity of the fraction from Schisandra chinensis fruit extract based on multi-technology integrated network pharmacology. Journal of Ethnopharmacology, 2023, 301, 115769.
  6. Jiushi Liu, Yumeng Wang, Bin Li, Yaodong Qi, Xueping Wei, Haitao Liu*, Bengang Zhang, Peigen Xiao. The effective approach for the quality control of Codonopsis radix based on quality markers of immune activity. Journal of Separation Science, 2022, 45(7): 1317-1325.
  7. Jiushi Liu#, Xinlu Mu#, Jinmei Liang, Jianuo Zhang, Tingyan Qiang, Hongbo Li, Bin Li, Haitao Liu*, Bengang Zhang. Metabolic profiling on the analysis of different parts of Schisandra chinensis based on UPLC-QTOF-MS with comparative bioactivity assays. Frontiers in Plant Science, 2022, 16648714: 192.
  8. Tingyan Qiang, Jiushi Liu, Yuqing Dong, Xinlu Mu, Yu Chen, Hongmei Luo, Bengang Zhang, Haitao Liu*. Identification, Molecular Cloning, and Functional Characterization of a Coniferyl Alcohol Acyltransferase Involved in the Biosynthesis of Dibenzocyclooctadiene Lignans in Schisandra chinensis. Frontiers in Plant Science, 2022, 13: 881342.
  9. Bin Li, Qi Xiao, Jiushi Liu, Xinlu Mu, Jianuo Zhang, Yaodong Qi, Bengang Zhang, Peigen Xiao, Haitao Liu*. Chemical characterization and potential mechanism of the anti-asthmatic activity of a subfraction from Schisandra chinensis fruit extract. Journal of Agricultural and Food Chemistry, 2022, 70, 5015–5025.
  10. Qi Xiao, Xinlu Mu, Jiushi Liu1, Bin Li, Haitao Liu*, Bengang Zhang, Peigen Xiao. Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials, 2022, Chin Med, 17:45.
  11. Xueping Wei, Xiaoyi Zhang, Yuqing Dong, Jilong Cheng, Yunjun Bai, Jiushi Liu, Yaodong Qi, Bengang Zhang, Haitao Liu*. Molecular structure and phylogenetic analyses of the complete chloroplast genomes of three medicinal plants Conioselinum vaginatum, Ligusticum sinense, and Ligusticum jeholense. Frontiers in Plant Science, 2022. 13: 878263.
  12. Yuqing Dong#, Xueping Wei#, Tingyan Qiang, Jiushi Liu, Peng Che, Yaodong Qi, Bengang Zhang, Haitao Liu*. RAD-seq and ecological niche reveal genetic diversity, phylogeny, and geographic distribution of Kadsura interior and its closely related species. Frontiers in Plant Science, 2022. 13: 857016.
  13. Xueping Wei, Xianchun Zhang*. Phylogeography of the widespread fern Lemmaphyllum in East Asia: species differentiation and population dynamics in response to change in climate and geography. Journal of Systematics and Evolution. 2022, 60(2): 411–432.
  14. Fan Li, Bin Li1 , Jiushi Liu, Xueping Wei, Tingyan Qiang, Xinlu Mu, Yumeng Wang, Yaodong Qi, Bengang Zhang, Haitao Liu*, Peigen Xiao. Anti-asthmatic fraction screening and mechanisms prediction of Schisandrae Sphenantherae Fructus based on a combined approach. Frontiers in Pharmacology, 2022, 13:902324.
  15. Xinlu Mu, Jiushi Liu, Bin Li, Xueping Wei, Yaodong Qi, Bengang Zhang, Haitao Liu*, Peigen Xiao. A comparative study on chemical characteristics, antioxidant, and hepatoprotective activity from different parts of Schisandrae Chinensis Fructus. Journal of Food Processing and Preservation, 2022: e16990.
  16. Jing Xu, Jiushi Liu, Bin Li, Xueping Wei, Yaodong Qi, Bengang Zhang, Haitao Liu*, Peigen Xiao. Comparison of blood tonic efficacy and chemical constituents of Kadsura interior A.C. Smith and its closely related species. Chinese Medicine. 2022, 17(1): 14.
  17. Jiushi Liu, Yumeng Wang, Bin Li, Yaodong Qi, Xueping Wei, Haitao Liu*, Bengang Zhang, Peigen Xiao. The effective approach for the quality control of Codonopsis radix based on quality markers of immune activity. Journal of Separation Science, 2022, 45(7): 1317–1325.
  18. Hongyu Chen(#), Miaoxian Guo(#), Shuting Dong(#), Xinling Wu, Guobin Zhang, Liu He,Yuannian Jiao,Shilin Chen*, Li Li*, Hongmei Luo*. A chromosome-scale genome assembly of Artemisia argyi reveals unbiased subgenome evolution and key contributions of gene duplication to volatile terpenoid diversity. Plant Communications, 2023, 4:100516
  19. Hongmei Luo(#),Jun Qian(#), Zhichao Xu,Wanjing Liu, Lei Xu,Ying Li,Jiang Xu, Jianhong Zhang,Xiaolan Xu,Chang Liu,Liu He,Jianqin Li,Chao Sun, Martin Francis*,Jingyuan Song*, Shilin Chen*. The Wolfiporia cocos genome and transcriptome shed light on the formation of its edible and medicinal sclerotium. Genomics Proteomics & Bioinformatics, 2020, 18: 455−467
  20. Haibin Xu(#),Jingyuan Song(#),Hongmei Luo(#), Yujun Zhang,Qiushi Li, Yingjie Zhu,Jiang Xu,Ying Li, Chi Song,Bo Wang,Wei Sun,Guoan Shen,Xin Zhang,Jun Qian,Aijia Ji,Zhichao Xu,Xiang Luo, Liu He,Chuyuan Li,Chao Sun,Haixia Yan, Guanghong Cui,Xiwen Li,Xian’en Li,Jianhe Wei,Juyan Liu,Yitao Wang, Hayward Alice, Nelson David, Zemin Ning, Peters Reuben J.,Xiaoquan Qi, Shilin Chen. Analysis of the genome sequence of the medicinal plant Salvia miltiorrhiza. Molecular Plant, 2016, 9(6):949−952.
  21. Haizhou Lv, Xin Zhang, Baosheng Liao, Wanjing Liu, Liu He, Jingyuan Song, Chao Sun,Hongmei Luo*,Shilin Chen*. Cloning and analysis of 1-hydroxy-2-methyl-2-(E)-butenyl- 4-diphosphate reductase genes HsHDR1 and HsHDR2 in Huperzia serrate. Acta Pharmaceutica Sinica B, 2015, 5(6):583–589.
  22. Hongmei Luo(#), Yingjie Zhu(#), Jingyuan Song,Chao Sun, Lijia Xu, Xin Zhang, Yanhong Xu, Liu He, Wei Sun, Haibin Xu, Bo Wang, Xian’en Li, Chuyuan Li, Juyan Liu, Shilin Chen*. Transcriptional data mining of Salvia miltiorrhiza in response to methyl jasmonate to examine the mechanism of bioactive compound biosynthesis and regulation. Physiologia Plantarum, 2014,152: 241−255.
  23. Hongmei Luo(#), Ying Li(#), Chao Sun, Qiong Wu, Yongzhen Sun, Jingyuan Song, Steinmetz André*, Shilin Chen*. Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. BMC Plant Biology, 2010, 10: 209.
  24. Cao Hongbo, Hongmei Luo, Hui Yuan, Eissa Mohamed A, Thannhauser Theodore W, Welsch Ralf, Yu-Jin Hao, Lailiang Cheng, Li Li*. A neighboring aromatic-aromatic amino acid combination governs activity divergence between tomato phytoene synthases. Plant Physiology, 2019, 180(4): 1988−2003.
  25. Zhichao Xu(#), Peters Reuben J.(#), Weirather Jason, Hongmei Luo, Baosheng Liao, Xin Zhang, Yingjie Zhu, Aijia Ji, Bing Zhang, Songnian Hu, Au Kin Fai, Jingyuan Song*, Shilin Chen*. Full-length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and tanshinone biosynthesis. Plant Journal, 2015, 82: 951–961.
  26. Xiwen Li(#), Huanhuan Gao(#), Yitao Wang, Jingyuan Song, Henry Robert, Hezhen Wu, Zhigang Hu, Hui Yao, Hongmei Luo, Kun Luo, Honglin Pan, Shilin Chen*. Complete chloroplast genome sequence of Magnolia grandiflora and comparative analysis with related species. Science China-Life Sciences, 2013, 56(2): 189−198.
  27. Shilin Chen(#)*, Jiang Xu(#), Chang Liu(#), Yingjie Zhu, Nelson David R., Shiguo Zhou, Chunfang Li, Lizhi Wang, Xu Guo, Yongzhen Sun, Hongmei Luo, Ying Li, Jingyuan Song, Henrissat Bernard, Levasseur Anthony, Jun Qian, Jianqin Li, Xiang Luo, Linchun Shi, Liu He, Li Xiang, Xiaolan Xu, Yunyun Niu, Qiushi Li, Han Mira V., Haixia Yan, Jin Zhang, Haimei Chen, Aiping Lv, Zhen Wang, Mingzhu Liu, Schwartz David C., Chao Sun*. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nature Communications, 2012, 3:913.
  28. Shilin Chen*#, Xiaohui Pang#, JingyuanSong*, Linchun Shi, Hui Yao, Jianping Han, Christine Leon. A renaissance in herbal medicine identification: From morphology to DNA. Biotechnology Advances, 2014, 32: 1237-1244.
  29. Mengyue Guo, Wenjun Jiang, Jingsheng Yu, XiaohuiPang*. Investigating the authenticity of Ophiopogonis Radix and its Chinese patent medicines by using a nucleotide signature. Journal of Ethnopharmacology, 2020, 261: 113134.
  30. Wenjun Jiang, Mengyue Guo,Meihua Yang, Nitin Mantri, Xuyu Chen, Xiaohui Pang*. High-throughput analysis of fungal communities in Myristicae Semen. LWT-Food Science and Technology, 2020, 128: 109499.
  31. Mengyue Guo, Wenjun Jiang, Meihua Yang, Xiaowen Dou, Xiaohui Pang*. Characterizing fungal communities in medicinal and edible Cassiae Semen using high–throughput sequencing. International Journal of Food Microbiology, 2020, 319: 108496.
  32. Mengyue Guo#, Xiaohui Pang#*, Yanqin Xu, Wenjun Jiang, Baosheng Liao, Jingsheng Yu,Jiang Xu, Jingyuan Song, Shilin Chen*. Plastid genome data provide new insights into the phylogeny and evolution of the genus Epimedium. Journal of Advanced Research, 2022, 36: 175-185.
  33. Mengyue Guo, Jingsheng Yu, Yujie Dao, Wenjun Jiang, Xiaohui Pang*. DNA metabarcoding of fungal communities in Heshouwu (Polygonum multiflorum Thunb.). Food Control, 2022, 136: 108850.
  34. Chune Fan, Rong Xu, Mengyue Guo, Wenjun Jiang, Meihua Yang, Yujie Dao, Xiaohui Pang*. Profiling of fungal communities in functional food Cistanches herba using high–throughput sequencing. Food Bioscience, 2024, 59: 103869.
  35. Wenjun Jiang, Mengyue Guo, Jingsheng Yu, Chune Fan, Meihua Yang, Xiaohui Pang*. Variations of the fungal microbiome in Corydalis Rhizoma with different collection areas, processing methods, and storage conditions. Food Research International, 2024, 180: 114045.
  36. Miaoxian Guo, Haizhou Lv, Hongyu Chen, Shuting Dong, Jianhong Zhang, Wanjing Liu, Liu He, Yimian Ma, Hua Yu, Shilin Chen, Hongmei Luo*. Strategies on biosynthesis and production of bioactive compounds in medicinal plants. Chinese herbal medicines, 2024, 16 (1): 13-26.
  37. Yimian Ma#, Jiadong Ran#, Guoqiong Li, Mengchen Wang, Chengmin Yang, Xin Wen, Xin Geng, Liping Zhang, Yuan Li*, Zheng Zhang*. Revealing the roles of the JAZ family in defense signaling and the agarwood formation process in Aquilaria sinensis. International journal of molecular science, 2023, 24 (12): 9872.
  38. Mingjun Yang#, Yimian Ma#, Xupeng Si, Xiaofeng Liu, Xin Geng, Xin Wen, Guoqiong Li, Liping Zhang, Chengmin Yang and Zheng Zhang*. Analysis of the glycoside hydrolase family 1 from wild jujube reveals genes involved in the degradation of Jujuboside A. Genes, 2023, 14, 1135.
  39. Jiadong Ran, Yuan Li, Xin Wen, Xin Geng, Xupeng Si, Liping Zhang, Yimian Ma*, Zheng Zhang*. Identification of sesquiterpene synthase genes in the genome of Aquilaria sinensis and characterization of an α humulene synthase, Journal of forestry research, 2023, 34:1117-1131.
  40. Jiang He, Weijun Yang, Bo Cheng, Lina Ma, Dilinuer Tursunjiang, Zimian Ding, Yong Li, Zhaofeng Wang, Yimian Ma* and Guan Li*. Integrated metabolomic and transcriptomic profiling reveals the tissue-specific flavonoid compositions and their biosynthesis pathways in Ziziphora Bungeana. Chinese medicine, 2020, 15:73.
  41. Miaomiao Liu#, Yimian Ma#, Qing Du, XueminHou, Meizhen Wang, Shanfa Lu*. Functional analysis of polyprenyldiphosphate synthase genes involved in plastoquinone and ubiquinone biosynthesis in Salvia miltiorrhiza. Frontiers in Plant Science, 2019, 10: article 893, doi: 10.3389/fpls.2019.00893
  42. Ying Ren, Gang Wang, Yuying Su, Jinfeng Li, Hui Zhang, Jianping Han, Response of antioxidant activity, active constituent and rhizosphere microorganisms of Salvia miltiorrhiza to combined application of microbial inoculant, microalgae and biochar under Cu stress, Science of The Total Environment, 2024,925,171812.
  43. Ren Ying, Gang Wang, Xuanjiao Bai, Yuying Su, Zheng Zhang, and Jianping Han, Research Progress on Remediation of Organochlorine Pesticide Contamination in Soil, Environmental Geochemistry and Health, 2024, 46.1, 25 .
  44. Wang, Gang, Ying Ren, Yuying Su, Hui Zhang, Jinfeng Li, Hongxia Zhao, Jianping Han, Identification of Toxic Gelsemium Elegans in Processed Food and Honey Based on Real-Time PCR Analysis, Food Research International, 2024, 182,114188.
  45. Gang Wang, Xuanjiao Bai, Ying Ren, Yuying Su, and Jianping Han, Development of Nucleotide Signatures for Common Poisonous Organisms Provides a New Strategy for Food Poisoning Diagnosis, Ecotoxicology and Environmental Safety, 2023, 265 ,115529 .
  46. Xuemin Wei, Xuanjiao Bai, Pei Cao, Gang Wang, Jianping Han, and Zheng Zhang, Bacillus and Microalgae Biofertilizers Improved Quality and Biomass of Salvia Miltiorrhiza by Altering Microbial Communities, Chinese Herbal Medicines, 2023,15.1, 45–56.
  47. Xuanjiao Bai, Gang Wang, Ying Ren, and Jianping Han, Detection of Highly Poisonous Nerium Oleander Using Quantitative Real-Time PCR with Specific Primers, Toxins, 2022, 14.11, 776 .
  48. Xuanjiao Bai, Gang Wang, Ying Ren, Yuying Su, and Jinping Han, Insights into Taxonomy and Phylogenetic Relationships of Eleven Aristolochia Species Based on Chloroplast Genome, Frontiers in Plant Science, 2023, 14 ,1119041 .
  49. Gang Wang, Ying Ren, Xuanjiao Bai, Yuying Su, and Jianping Han, Contributions of Beneficial Microorganisms in Soil Remediation and Quality Improvement of Medicinal Plants, Plants (Basel, Switzerland), 2022, 11.23 ,3200.
  50. Gang Wang, Yang Liu, Xuanjiao Bai, Pei Cao, Xiaohui Pang, and Jianping Han, Identification and Poisoning Diagnosis of Aconitum Materials Using a Genus-Specific Nucleotide Signature, Ecotoxicology and Environmental Safety, 2022, 237 ,113539.
  51. Gang Wang, Xuanjiao Bai, Xiaochen Chen, Ying Ren, Xiaohui Pang, and Jianping Han, Detection of Adulteration and Pesticide Residues in Chinese Patent Medicine Qipi Pill Using KASP Technology and GC-MS/MS, Frontiers in Nutrition,2022, 9 , 837268.
  52. Gang Wang, Xuanjiao Bai, Xiaochen Chen, Ying Ren, and Jianping Han, Development of a Genus-Universal Nucleotide Signature for the Identification and Supervision of Ephedra-Containing Products, Molecules, 2022, 27.7, 2342.
  53. Xuemin Wei, Pei Cao, Gang Wang, Yang Liu, Jingyuan Song, and Jianping Han, CuO, ZnO, and γ-Fe2O3 Nanoparticles Modified the Underground Biomass and Rhizosphere Microbial Community of Salvia Miltiorrhiza (Bge.) after 165-Day Exposure, Ecotoxicology and Environmental Safety, 2021, 217 ,112232.
  54. Pei Cao, Gang Wang, Xue-min Wei, Shi-lin Chen, and Jian-ping Han, How to Improve CHMs Quality: Enlighten from CHMs Ecological Cultivation, Chinese Herbal Medicines, 2021,13.3, 301–12.
  55. Xuemin Wei, Pei Cao, Gang Wang, and Jianping Han, Microbial Inoculant and Garbage Enzyme Reduced Cadmium (Cd) Uptake in Salvia Miltiorrhiza (Bge.) under Cd Stress, Ecotoxicology and Environmental Safety, 2020, 192, 110311.
  56. XiaoYue Wang, Rong Xu, Jun Chen, JingYuan Song, Steven G. Newmaster, JianPing Han, Zheng Zhang, Shilin Chen, Detection of Cistanches Herba (Rou Cong Rong) Medicinal Products Using Species-Specific Nucleotide Signatures, Frontiers in Plant Science, 2018, 9, 1643.
  57. Yang Liu, Xiaoyue Wang, Xuemin Wei, Zitong Gao, and Jianping Han, Rapid Authentication of Ginkgo Biloba Herbal Products Using the Recombinase Polymerase Amplification Assay, Scientific Reports, 2018, 8.1, 8002.
  58. Yang Liu, Xiaoyue Wang, Zitong Gao, Jianping Han, and Li Xiang, Detection of Ophiocordyceps Sinensis and Its Common Adulterates Using Species-Specific Primers, Frontiers in Microbiology, 2017, 8, 1179.
  59. Yang Liu, Xiaoyue Wang, Lili Wang, Xiaochen Chen, Xiaohui Pang, and Jianping Han, A Nucleotide Signature for the Identification of American Ginseng and Its Products, Frontiers in Plant Science, 2016, 7
  60. Xiaochen Chen, Qiushi Li, Ying Li, Jun Qian, and Jianping Han, Chloroplast Genome of Aconitum Barbatum Var. Puberulum (Ranunculaceae) Derived from CCS Reads Using the PacBio RS Platform, Frontiers in Plant Science, 2015, 6.