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资源学

2023年11月07日

专业特色

资源中心自建所以来成立，发展历史悠久，至今形成了涵盖药用植物资源调查、分类鉴定、保护与利用；种质资源收集与品质评价、优良品质形成机制；药效物质基础及合同通路解析等多个研究方向，开设《药用植物资源学》、《药用植物分类与实践》、《药用植物品质生物学》等课程，形成了以植物学为基础，遗传学、生理学、植物化学、药理学等学科交叉为特色的综合科研与教学中心。

研究方向

1、药用植物资源调查与评估； 2、药用植物分类与鉴定；3、药用植物保护与开发；4、药用植物优良品质及性状形成机制研究； 5、药用植物种质资源收集及品质评价；6、药材规范化种植技术，中药材质量评价；7、药用植物资源化学；；8、中药创新药物研发；9、药用植物合成生物学。

科研水平

资源中心在药用植物资源调查、中药材品质评价等方向处于国内领先水平。（1）开展多个大宗常用药材品种的资源调查和栽培标准技术集成研究，对我国464种重要且濒危的药用植物开展了资源调查与评估，出版《药用植物红皮书》；（2）开展了大宗药材黄芪、党参、贝母、五味子等药材的中药质量评价；（3）围绕中药活性成分生物合成及调控机制研究，关注丹参、艾叶、茯苓等大宗药材的品质形成机制解析及其产品开发，重点开展药用植物逆境生理与药材品质形成相关性研究，同时开展药用植物优良性状相关分子标记开发及其辅助中药材新品种选育等方面研究工作；（4）开展了中药材表面污染真菌鉴定研究。

重大课题

资源中心先后承担各类国家级、省部级科研项目80余项，其中包括国家自然科学基金、海外优青、国家重点研发计划项目、“重大新药创制”科技重大专项、国家中药标准化项目、科技部科技基础性工作专项、国家中医药管理局中医药行业科研专项、科技部“十二·五”国家科技支撑计划项目等项目。

发表文章及科研成果

 主持编写专著10余部，包括《中国药用植物红皮书》、《中国药典中药材DNA 条形码标准序列》、《药用植物科普笔记》等，发表科研论文500余篇。

获得国家科学技术进步二等奖及省部级等重要奖项10余项；获授权发明专利20余项，软件著作权10余项。参与制定国家、行业及地方标准20余项。

代表性成果：

  1. Zhiwei Li†, Yufan Feng†, Haitao Liu†, Hongqin Yang, Jinqiu Li, Yitian Zhou, Junling Pang, Peiran Yang, Hongmei Zhao*, Jing Wang*. Single-cell transcriptomics of mouse lung reveal inflammatory memory neutrophils in allergic asthma. Allergy. 2022, 77(6): 1911-1915.
  2. Zhangjian Shan#, Qian Zhang#, Yaodong Qi#, Jianfei Ye, Dacheng Hao, Peigen Xiao, Lan Cao, Jiahui Sun, Lina Zhao, Yanting Niu, Danxiao Peng, Limin Lu, Zhiduan Chen. Production regionalization of commonly used medicinal plants in China based on botanical big data. Industrial Crops and Products, 2023, 202: 117024.
  3. Ruyu Yao, Michael Heinrich, Bengang Zhang, Xueping Wei, Yaodong Qi*, Weiwei Gao1*. Single botanical drugs in the Ayurvedic Pharmacopoeia of India—A quantitative ethnobotanical analysis. Frontiers in Pharmacology, 2023, 14: 1136446.
  4. Jiejing Gao, Tiantian Xue, Changying Xia, Chunfeng Tang, Fei Qin, Xudong Yang, Jiaxin Wang, Yunfeng Huang, Yaodong Qi*, Rainer W. Bussmann*, Chong Luo*, Shengxiang Yu*. Priority management measures based on analyses of conservation effectiveness and threat factors for medicinal plants used by three ethnic groups in China. Biological Conservation, 2023, 283: 110120.
  5. Bin Li#, Qi Xiao#, Jianuo Zhang, Yumeng Wang, Jiushi Liu, Bengang Zhang, Haitao Liu*. Exploring the active compounds and potential mechanism of the anti-nonalcoholic fatty liver disease activity of the fraction from Schisandra chinensis fruit extract based on multi-technology integrated network pharmacology. Journal of Ethnopharmacology, 2023, 301, 115769.
  6. Jiushi Liu, Yumeng Wang, Bin Li, Yaodong Qi, Xueping Wei, Haitao Liu*, Bengang Zhang, Peigen Xiao. The effective approach for the quality control of Codonopsis radix based on quality markers of immune activity. Journal of Separation Science, 2022, 45(7): 1317-1325.
  7. Jiushi Liu#, Xinlu Mu#, Jinmei Liang, Jianuo Zhang, Tingyan Qiang, Hongbo Li, Bin Li, Haitao Liu*, Bengang Zhang. Metabolic profiling on the analysis of different parts of Schisandra chinensis based on UPLC-QTOF-MS with comparative bioactivity assays. Frontiers in Plant Science, 2022, 16648714: 192.
  8. Tingyan Qiang, Jiushi Liu, Yuqing Dong, Xinlu Mu, Yu Chen, Hongmei Luo, Bengang Zhang, Haitao Liu*. Identification, Molecular Cloning, and Functional Characterization of a Coniferyl Alcohol Acyltransferase Involved in the Biosynthesis of Dibenzocyclooctadiene Lignans in Schisandra chinensis. Frontiers in Plant Science, 2022, 13: 881342.
  9. Bin Li, Qi Xiao, Jiushi Liu, Xinlu Mu, Jianuo Zhang, Yaodong Qi, Bengang Zhang, Peigen Xiao, Haitao Liu*. Chemical characterization and potential mechanism of the anti-asthmatic activity of a subfraction from Schisandra chinensis fruit extract. Journal of Agricultural and Food Chemistry, 2022, 70, 5015–5025.
  10. Qi Xiao, Xinlu Mu, Jiushi Liu1, Bin Li, Haitao Liu*, Bengang Zhang, Peigen Xiao. Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials, 2022, Chin Med, 17:45.
  11. Xueping Wei, Xiaoyi Zhang, Yuqing Dong, Jilong Cheng, Yunjun Bai, Jiushi Liu, Yaodong Qi, Bengang Zhang, Haitao Liu*. Molecular structure and phylogenetic analyses of the complete chloroplast genomes of three medicinal plants Conioselinum vaginatum, Ligusticum sinense, and Ligusticum jeholense. Frontiers in Plant Science, 2022. 13: 878263.
  12. Yuqing Dong#, Xueping Wei#, Tingyan Qiang, Jiushi Liu, Peng Che, Yaodong Qi, Bengang Zhang, Haitao Liu*. RAD-seq and ecological niche reveal genetic diversity, phylogeny, and geographic distribution of Kadsura interior and its closely related species. Frontiers in Plant Science, 2022. 13: 857016.
  13. Xueping Wei, Xianchun Zhang*. Phylogeography of the widespread fern Lemmaphyllum in East Asia: species differentiation and population dynamics in response to change in climate and geography. Journal of Systematics and Evolution. 2022, 60(2): 411–432.
  14. Fan Li, Bin Li1 , Jiushi Liu, Xueping Wei, Tingyan Qiang, Xinlu Mu, Yumeng Wang, Yaodong Qi, Bengang Zhang, Haitao Liu*, Peigen Xiao. Anti-asthmatic fraction screening and mechanisms prediction of Schisandrae Sphenantherae Fructus based on a combined approach. Frontiers in Pharmacology, 2022, 13:902324.
  15. Xinlu Mu, Jiushi Liu, Bin Li, Xueping Wei, Yaodong Qi, Bengang Zhang, Haitao Liu*, Peigen Xiao. A comparative study on chemical characteristics, antioxidant, and hepatoprotective activity from different parts of Schisandrae Chinensis Fructus. Journal of Food Processing and Preservation, 2022: e16990.
  16. Jing Xu, Jiushi Liu, Bin Li, Xueping Wei, Yaodong Qi, Bengang Zhang, Haitao Liu*, Peigen Xiao. Comparison of blood tonic efficacy and chemical constituents of Kadsura interior C. Smith and its closely related species. Chinese Medicine. 2022, 17(1): 14.
  17. Jiushi Liu, Yumeng Wang, Bin Li, Yaodong Qi, Xueping Wei, Haitao Liu*, Bengang Zhang, Peigen Xiao. The effective approach for the quality control of Codonopsis radix based on quality markers of immune activity. Journal of Separation Science, 2022, 45(7): 1317–1325.
  18. Chen Hongyu(#), Guo Miaoxian(#), Dong Shuting(#), Wu Xinling, Zhang Guobin, He Liu, Jiao Yuannian, Chen Shilin*, Li Li*, Luo Hongmei*. A chromosome-scale genome assembly of Artemisia argyi reveals unbiased subgenome evolution and key contributions of gene duplication to volatile terpenoid diversity. Plant Communications, 2023, 4:100516
  19. Luo Hongmei(#), Qian Jun(#), Xu Zhichao, Liu Wanjing, Xu Lei, Li Ying, Xu Jiang, Zhang Jianhong, Xu Xiaolan, Liu Chang, He Liu, Li Jianqin, Sun Chao, Martin Francis*, Song Jingyuan*, Chen Shilin*. The Wolfiporia cocos genome and transcriptome shed light on the formation of its edible and medicinal sclerotium. Genomics Proteomics & Bioinformatics, 2020, 18: 455−467
  20. Xu Haibin(#),Song Jingyuan (#),Luo Hongmei (#),Zhang Yujun, Li Qiushi, Zhu Yingjie, Xu Jiang, Li Ying, Song Chi, Wang Bo, Sun Wei, Shen Guoan, Zhang Xin, Qian Jun, Ji Aijia, Xu Zhichao, Luo Xiang, He Liu, Li Chuyuan, Sun Chao, Yan Haixia, Cui Guanghong, Li Xiwen, Li Xian’en, Wei Jianhe, Liu Juyan, Wang Yitao, Hayward Alice, Nelson David, Ning Zemin, Peters Reuben J., Qi Xiaoquan, Chen Shilin. Analysis of the genome sequence of the medicinal plant Salvia miltiorrhiza. Molecular Plant, 2016, 9(6):949−
  21. Lv Haizhou, Zhang Xin, Liao Baosheng, Liu Wanjing, He Liu, Song Jingyuan, Sun Chao, Luo Hongmei*, Chen Shilin*. Cloning and analysis of 1-hydroxy-2-methyl-2-(E)-butenyl- 4-diphosphate reductase genes HsHDR1 and HsHDR2 in Huperzia serrate. Acta Pharmaceutica Sinica B, 2015, 5(6):583–589.
  22. Luo Hongmei(#), Zhu Yingjie(#), Song Jingyuan, Sun Chao, Xu Lijia, Zhang Xin, Xu Yanhong, He Liu, Sun Wei, Xu Haibin, Wang Bo, Li Xian’en, Li Chuyuan, Liu Juyan, Chen Shilin*. Transcriptional data mining of Salvia miltiorrhiza in response to methyl jasmonate to examine the mechanism of bioactive compound biosynthesis and regulation. Physiologia Plantarum, 2014,152: 241−
  23. Luo Hongmei(#), Li Ying(#), Sun Chao, Wu Qiong, Sun Yongzhen, Song Jingyuan, Steinmetz André*, Chen Shilin*. Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. BMC Plant Biology, 2010, 10: 209.
  24. Cao Hongbo, Luo Hongmei, Yuan Hui, Eissa Mohamed A, Thannhauser Theodore W, Welsch Ralf, Hao Yu-Jin, Cheng Lailiang, Li Li*. A neighboring aromatic-aromatic amino acid combination governs activity divergence between tomato phytoene synthases. Plant Physiology, 2019, 180(4): 1988−
  25. Xu Zhichao(#), Peters Reuben J.(#), Weirather Jason, Luo Hongmei, Liao Baosheng, Zhang Xin, Zhu Yingjie, Ji Aijia, Zhang Bing, Hu Songnian, Au Kin Fai, Song Jingyuan*, Chen Shilin*. Full-length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and tanshinone biosynthesis. Plant Journal, 2015, 82: 951–961.
  26. Li Xiwen(#), Gao Huanhuan(#), Wang Yitao, Song Jingyuan, Henry Robert, Wu Hezhen, Hu Zhigang, Yao Hui, Luo Hongmei, Luo Kun, Pan Honglin, Chen Shilin*. Complete chloroplast genome sequence of Magnolia grandiflora and comparative analysis with related species. Science China-Life Sciences, 2013, 56(2): 189−
  27. Chen Shilin(#)*, Xu Jiang(#), Liu Chang(#), Zhu Yingjie, Nelson David R., Zhou Shiguo, Li Chunfang, Wang Lizhi, Guo Xu, Sun Yongzhen, Luo Hongmei, Li Ying, Song Jingyuan, Henrissat Bernard, Levasseur Anthony, Qian Jun, Li Jianqin, Luo Xiang, Shi Linchun, He Liu, Xiang Li, Xu Xiaolan, Niu Yunyun, Li Qiushi, Han Mira V., Yan Haixia, Zhang Jin, Chen Haimei, Lv Aiping, Wang Zhen, Liu Mingzhu, Schwartz David C., Sun Chao*. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nature Communications, 2012, 3:913.

师资力量及人才培养

中心现有职工16名，含博士生导师5名，硕士生导师5名。本中心拥有海外优青获得者、“协和新星”、北京市及协和医学院优秀教师等多项荣誉称号。几十年来，先后培养硕士、博士毕业生100多人。